Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | ME2 | P23368 | 1/20 | 0.34 |
| ▸ | ME1 | P48163 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736432 | 0.84 | GRM5 (0.44) | GRM5CNR2KMT2AOGANMT1 | |
| SCHEMBL4609788 | 0.80 | ME2 (0.43) | CNR2KMT2AOGAAOC3DRD2 | |
| SCHEMBL27736429 | 0.78 | GRM5 (0.48) | GRM5KMT2AOGAAOC3DRD2 | |
| SCHEMBL1902271 | 0.74 | GRM5 (0.73) | GRM5ME2ME1ME3 | |
| SCHEMBL2124732 | 0.71 | CNR2 (0.49) | CNR2KMT2AOGAAOC3DRD2 | |
| SCHEMBL27736425 | 0.69 | GRM5 (0.45) | GRM5CNR2KMT2AOGANMT1 | |
| SCHEMBL4611088 | 0.68 | SMN1; SMN2 (0.43) | GRM5KMT2ADRD2DRD4DRD3 | |
| SCHEMBL4608986 | 0.67 | HRH3 (0.40) | GRM5DRD2DRD4DRD3HTR7 | |
| SCHEMBL4610865 | 0.67 | IDO1 (0.42) | GRM5SLC6A3DRD2DRD3 | |
| SCHEMBL27736430 | 0.66 | GRM5 (0.43) | GRM5CNR2OGAAOC3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |