Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 1/20 | 0.43 |
| ▸ | ME1 | P48163 | 1/20 | 0.43 |
| ▸ | ME3 | Q16798 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736434 | 0.84 | MAPK1 (0.48) | ME2ME1ME3MAPK1ALDH1A1 | |
| SCHEMBL4608871 | 0.81 | KDM4E (0.41) | ALDH1A1SMN1; SMN2KDM4EDRD4DRD5 | |
| SCHEMBL4609858 | 0.80 | GRM5 (0.41) | ME2ME1ME3CNR2OGA | |
| SCHEMBL27736431 | 0.78 | MAPK1 (0.51) | ME2ME1ME3MAPK1ALDH1A1 | |
| SCHEMBL1903052 | 0.74 | ME2 (0.59) | ME2ME1ME3ALDH1A1HPGD | |
| SCHEMBL2124732 | 0.71 | CNR2 (0.49) | ALDH1A1CNR2OGAKDM4EKMT2A | |
| SCHEMBL27736425 | 0.71 | GRM5 (0.45) | MAPK1ALDH1A1CNR2OGAKMT2A | |
| SCHEMBL4608986 | 0.69 | HRH3 (0.40) | ME2ME1ME3DRD4DRD5 | |
| SCHEMBL4610798 | 0.66 | GRM5 (0.54) | ME2ME1ME3DRD4DRD2 | |
| SCHEMBL4611088 | 0.66 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2KDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |