Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637877 | 0.82 | BTK (0.44) | BTKHRH3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL1296378 | 0.82 | BTK (0.50) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL25762342 | 0.82 | BTK (0.50) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL1690233 | 0.81 | HRH3 (0.49) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL1298062 | 0.81 | HRH3 (0.43) | BTKHRH3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL20765967 | 0.78 | CHRM2 (0.44) | BTKHRH3CHRNB2CHRNA4CHRM2 | |
| SCHEMBL1758681 | 0.78 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRM2CHRM3KMT2A | |
| SCHEMBL1764699 | 0.77 | HRH3 (0.49) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL186721 | 0.77 | HRH3 (0.51) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL1295721 | 0.77 | HRH3 (0.51) | BTKHRH3CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907359-A2 | 3,5-SUBSTITUTED PIPERIDINE DERIVATIVES EFFECTIVE ON RENIN-RELATED DISORDERS | Novartis AG (CH) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007006534-A2 | PIPERIDINE DERIVATIVES USEFUL IN THE DIAGNOSTIC AND THERAPEUTIC TREATMENT OF DISEASES DEPENDING ON RENIN ACTIVITY | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | disclosed |