Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590911 | 0.80 | TACR1 (0.36) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4592438 | 0.79 | POLB (0.43) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4591434 | 0.75 | TACR1 (0.35) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4592111 | 0.74 | MBTPS1 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2THRB | |
| SCHEMBL4590615 | 0.74 | POLB (0.41) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4591405 | 0.73 | POLB (0.43) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4591790 | 0.73 | SLC6A4 (0.36) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4591677 | 0.72 | POLB (0.42) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4591502 | 0.70 | HDAC3 (0.40) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4591595 | 0.70 | HDAC3 (0.39) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | disclosed |