Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 5/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591502 | 0.92 | HDAC3 (0.40) | HDAC3HDAC8HDAC6SLC6A4SLC6A2 | |
| SCHEMBL4591391 | 0.87 | HDAC3 (0.42) | HDAC3HDAC8HDAC6SLC6A4SLC6A2 | |
| SCHEMBL4590753 | 0.85 | REN (0.49) | HDAC3HDAC8HDAC6SLC6A4SLC6A2 | |
| SCHEMBL4591677 | 0.84 | POLB (0.42) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL4591790 | 0.82 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL4592111 | 0.81 | MBTPS1 (0.39) | SLC6A4SLC6A2SLC6A3KCNH2MBTPS1 | |
| SCHEMBL4590615 | 0.80 | POLB (0.41) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL4591405 | 0.79 | POLB (0.43) | SLC6A4SLC6A2SLC6A3KCNH2TACR1 | |
| SCHEMBL4591451 | 0.79 | HDAC8 (0.43) | HDAC3HDAC8HDAC6SLC6A4SLC6A2 | |
| SCHEMBL4592042 | 0.78 | REN (0.48) | HDAC3HDAC8HDAC6SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | disclosed |