Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473141 | 0.89 | RXRA (0.60) | RXRANR1H2NR1H3PTGS2KLKB1 | |
| SCHEMBL3471400 | 0.84 | RXRA (0.60) | RXRANR1H2NR1H3PTGS2KLKB1 | |
| SCHEMBL3470980 | 0.84 | RXRA (0.57) | RXRANR1H2NR1H3PTGS2KLKB1 | |
| SCHEMBL3471811 | 0.83 | RXRA (0.65) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL3473874 | 0.83 | NR1H2 (0.67) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL3471406 | 0.83 | RXRA (0.67) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL14624005 | 0.82 | RXRA (0.61) | RXRANR1H2NR1H3PTGS2KLKB1 | |
| SCHEMBL3472855 | 0.82 | RXRA (0.64) | RXRANR1H2NR1H3PTGS2 | |
| SCHEMBL12980532 | 0.82 | RXRA (0.56) | RXRANR1H2NR1H3PTGS2KLKB1 | |
| SCHEMBL3471279 | 0.81 | RXRA (0.60) | RXRANR1H2NR1H3PTGS2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |