SCHEMBL461287

SCHEMBL461287

Fc1ccc2c(C3CCNCC3)noc2c1

nearest known ligand 0.61

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.61
DRD2 P14416 1/20 0.60
SLC6A4 P31645 1/20 0.60
SCD O00767 1/20 0.51
HTR2A P28223 1/20 0.48
HTR7 P34969 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL531052 0.99 ACHE (0.60) ACHEDRD2SLC6A4SCDHTR2A
SCHEMBL7726651 0.93 ACHE (0.55) ACHEDRD2SLC6A4HTR2A
SCHEMBL7356803 0.92 ACHE (0.55) ACHEDRD2SLC6A4SCDHTR2A
Hydrochloric Acid SCHEMBL1544936 0.90 ACHE (0.54) ACHEDRD2SLC6A4SCDHTR2A
Trifluoroacetic Acid SCHEMBL7453133 0.89 ACHE (0.51) ACHEDRD2SLC6A4HTR2AHTR7
SCHEMBL29688619 0.88 SCD (0.51) ACHEDRD2SLC6A4SCD
SCHEMBL187372 0.88 SCD (0.51) ACHEDRD2SLC6A4SCD
SCHEMBL4541441 0.88 ACHE (0.58) ACHEDRD2SLC6A4SCDHTR2A
Hydrochloric Acid SCHEMBL8916694 0.87 SCD (0.50) ACHEDRD2SLC6A4SCD
SCHEMBL20327895 0.85 ACHE (0.56) ACHEDRD2SLC6A4SCDHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 925 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036817-A C-alkyl carbon glycoside and preparation method thereof 江西师范大学 2026-05-15 CN claimed
CN-118852144-A Enaminones compounds with antioxidant stress activity, preparation and application thereof 中国医学科学院药物研究所 2024-10-29 CN claimed
CN-118561742-A Rupestonic acid amide derivative containing nitrogen heterocycle, and preparation method and application thereof 中国科学院新疆理化技术研究所 2024-08-30 CN claimed
CN-114163401-A Preparation method and application of N-benzenesulfonyl formamidine compound 商丘师范学院 2022-03-11 CN claimed
US-20180273906-A1 MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS IPS HEART 2018-09-27 US claimed
EP-2683717-B1 PREPARATION OF 3-[2-[4-((6-FLUORO-1, 2-BENZISOXAZOL-3-YL)-L-PIPERIDINYL)-6, 7, 8, 9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO[ 1, 2-A]-PYRIMIDIN-4-ONE (PALIPERIDONE) AND PALIPERIDONE PALMITATE. RAMAMOHAN RAO DAVULURI (IN) 2016-05-25 EP claimed
EP-2479176-B1 METHOD FOR PREPARATION OF ILOPERIDONE AND CRYSTALLIZATION METHOD THEREOF ZHEJIANG HUAHAI PHARM CO LTD (CN) 2014-09-17 EP claimed
US-20130190501-A1 PROCESSES FOR THE PREPARATION OF 4'-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY]-3'-METHOXYACETOPHENONE AND INTERMEDIATES THEREOF SYMED LABS LIMITED (IN) 2013-07-25 US claimed
CN-103012387-A Method for preparing iloperidone UNIV ZHEJIANG 2013-04-03 CN claimed
WO-2012153341-A1 A PROCESS FOR THE PREPARATION OF ILOPERIDONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF ARCH PHARMALABS LIMITED (IN) 2012-11-15 WO claimed
WO-2003010166-A1 NOVEL 2H-PYRIDAZINE-3-ONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE ACTIVE INGREDIENT EGIS Gyógyszergyár Rt. (HU) 2003-02-06 WO claimed
EP-1280804-A1 A PROCESS FOR THE PREPARATION OF ANTI-PSCHOTIC 3- 2- 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO 1,2,-A]PYRIMIDIN-4-ONE RPG Life Sciences Limited (IN) 2003-02-05 EP claimed
WO-2001085731-A1 A PROCESS FOR THE PREPARATION OF ANTI-PSCHOTIC 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2,-a]pyrimidin-4-one RPG LIFE SCIENCES LIMITED (IN) 2001-11-15 WO claimed
EP-0765323-B1 4-(6-FLUORO-1,2-BENZISOXAZOLYL)-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA AND ANXIETY FERRER INT (ES) 2001-07-11 EP claimed
US-5736558-A 4-(6-fluoro-1,2-benzisoxazolyl)-1 piperidinyl-propoxy-chromen-4-one-one-derivatives, their preparation and their use in the treatment of psychosis, schizophrenia and anxiety FERRER INTERNACIONAL, S.A. (ES) 1998-04-07 US claimed
EP-0765323-A1 4-(6-FLUORO-1,2-BENZISOXAZOLYL)-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA AND ANXIETY FERRER INTERNACIONAL, S.A. (ES) 1997-04-02 EP claimed
WO-1996032389-A1 4-(6-FLUORO-1,2-BENZISOXAZOLYL)-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA AND ANXIETY FERRER INTERNACIONAL, S.A. (ES) 1996-10-17 WO claimed
CN-1022566-C Process for preparing novel substituted 1-piperidinoalkylene-pyridopyrimidones or thiazolopyrimidinones JANSSEN PHARMACEUTICA NV (BE) 1993-10-27 CN claimed
CN-86101906-A Process for preparing 1, 2 benzisoxazol-3-yl and 1, 2 benzisothiazol-3-yl derivatives 1986-10-01 CN claimed
US-4355037-A ANALGESICS HOECHST-ROUSSEL PHARMACEUTICALS (US) 1982-10-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180273906-A1 MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS EXOSC9, EXOSC5, EXOSC4 ACHE 4785/4885DRD2 3540/4885SLC6A4 3953/4885
US-20130190501-A1 PROCESSES FOR THE PREPARATION OF 4'-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY]-3'-METHOXYACETOPHENONE AND INTERMEDIATES THEREOF CYP4B1, CYP4X1, CYP3A4 ACHE 2911/4885DRD2 2165/4885SLC6A4 3073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.