Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813395 | 0.82 | CHRM5 (0.46) | ADORA2ANPC1MPLUSP7 | |
| SCHEMBL27613072 | 0.78 | DHFR (0.59) | DHFRADORA1ADORA2A | |
| SCHEMBL4464780 | 0.78 | FGFR1 (0.55) | DHFRADORA1ADORA2A | |
| SCHEMBL28201122 | 0.78 | DHFR (0.51) | DHFR | |
| SCHEMBL4186547 | 0.78 | DHFR (0.56) | DHFRADORA1ADORA2ABCL6 | |
| SCHEMBL15648676 | 0.78 | ADORA2A (0.56) | ADORA1ALOX5APFEN1ADORA2ABCL6 | |
| SCHEMBL29114862 | 0.77 | DHFR (0.47) | DHFRADORA1ALOX5APFEN1ADORA2A | |
| SCHEMBL3959532 | 0.76 | DHFR (0.54) | DHFR | |
| SCHEMBL27612436 | 0.76 | DHFR (0.45) | DHFRADORA1ALOX5APFEN1BCL6 | |
| SCHEMBL1612797 | 0.76 | DHFR (0.45) | DHFRADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981856-A2 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085833-A2 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |