Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612609 | 0.81 | DHFR (0.51) | DHFRFGFR1 | |
| SCHEMBL1613741 | 0.77 | DHFR (0.55) | DHFRADORA1 | |
| SCHEMBL4613355 | 0.76 | DHFR (0.51) | DHFRADORA1 | |
| SCHEMBL30219604 | 0.76 | MAP3K14 (0.50) | — | |
| SCHEMBL28986232 | 0.76 | MAP3K14 (0.50) | — | |
| SCHEMBL27612436 | 0.75 | DHFR (0.45) | DHFRFGFR1RPS6KA3ADORA1 | |
| SCHEMBL1936800 | 0.74 | DHFR (0.57) | DHFRFGFR1ADORA1 | |
| SCHEMBL1388517 | 0.70 | DHFR (0.74) | DHFRFGFR1SRCADORA1 | |
| SCHEMBL28201122 | 0.69 | DHFR (0.51) | DHFRFGFR1 | |
| SCHEMBL8894121 | 0.69 | DHFR (0.47) | DHFRFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | DHFR 2398/4885FGFR1 816/4885SRC 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.