Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727428 | 0.85 | TDP2 (0.43) | TDP2HSD17B2SCN5ANR1H2NR1H3 | |
| SCHEMBL4611868 | 0.85 | HSD17B2 (0.48) | TDP2HSD17B2NR1H2NR1H3NPC1 | |
| SCHEMBL8299367 | 0.82 | PTGES (0.45) | TDP2HSD17B2SCN5ANR1H2NR1H3 | |
| SCHEMBL8300243 | 0.82 | PTGES (0.41) | TDP2SCN5ANR1H2NR1H3PTGES | |
| SCHEMBL8303862 | 0.81 | PTGES (0.42) | TDP2SCN5ANR1H2NR1H3PTGES | |
| SCHEMBL8298665 | 0.81 | MRGPRX4 (0.41) | TDP2 | |
| SCHEMBL5727234 | 0.80 | TDP2 (0.41) | TDP2SCN5ANR1H2NR1H3KCNH2 | |
| SCHEMBL5726584 | 0.79 | TDP2 (0.40) | TDP2SCN5ANR1H2NR1H3PTGES | |
| SCHEMBL8304787 | 0.79 | MAPT (0.41) | TDP2SCN5ANPC1RAB9APTGES | |
| SCHEMBL4611925 | 0.78 | PTGES (0.46) | TDP2HSD17B2NR1H2NR1H3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606269-B1 | BIARYL SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS | MERCK & CO INC (US) | 2008-10-29 | — | — | EP | claimed |
| EP-1606269-B1 | BIARYL SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS | MERCK & CO INC (US) | 2008-10-29 | — | — | EP | disclosed |