Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131373 | 0.80 | CYP1A2 (0.39) | ALOX15PLD2PLD1KDM4ECYP1A2 | |
| SCHEMBL30640267 | 0.80 | CYP1A2 (0.39) | ALOX15PLD2PLD1KDM4ECYP1A2 | |
| SCHEMBL31548709 | 0.73 | CYP1A2 (0.33) | PLD2PLD1KDM4ESMN1; SMN2CYP1A2 | |
| Acetohydroxamic Acid SCHEMBL28905392 | 0.69 | HDAC7 (0.52) | HDAC8HDAC6HDAC1HDAC2HDAC7 | |
| Hydroxyurea SCHEMBL8687113 | 0.69 | HDAC7 (0.52) | HDAC8HDAC6HDAC1HDAC2HDAC7 | |
| SCHEMBL15821065 | 0.67 | HDAC6 (0.44) | HDAC8HDAC6HDAC1HDAC2HDAC7 | |
| SCHEMBL20793908 | 0.66 | HCAR2 (0.43) | HSD17B10KDM4E | |
| SCHEMBL2521301 | 0.66 | CYP1A2 (0.46) | CA1ALOX15HSD17B10CYP1A2 | |
| SCHEMBL1143178 | 0.66 | CYP1A2 (0.40) | CA1ALOX15HSD17B10GAACYP1A2 | |
| SCHEMBL260496 | 0.65 | NOTUM (0.39) | HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613775-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |