Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | VDR | P11473 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617512 | 0.98 | MAPT (0.65) | MAPTRECQLMEN1LMNATHRB | |
| Bromide SCHEMBL4615096 | 0.97 | MAPT (0.63) | MAPTRECQLMEN1LMNATHRB | |
| Iodide SCHEMBL3852244 | 0.97 | MAPT (0.68) | MAPTRECQLMEN1LMNATHRB | |
| SCHEMBL4616667 | 0.93 | MAPT (0.58) | MAPTRECQLMEN1LMNATHRB | |
| SCHEMBL4614019 | 0.93 | MAPT (0.58) | MAPTRECQLMEN1LMNATHRB | |
| Sulfuric Acid SCHEMBL4614834 | 0.92 | KMT2A (0.57) | MAPTRECQLMEN1LMNATHRB | |
| SCHEMBL4615653 | 0.90 | MAPT (0.56) | MAPTRECQLMEN1LMNATHRB | |
| Sulfuric Acid SCHEMBL4615121 | 0.89 | MEN1 (0.55) | MAPTRECQLMEN1LMNATHRB | |
| Iodide SCHEMBL9692754 | 0.85 | MAPT (0.52) | MAPTRECQLMEN1LMNATHRB | |
| SCHEMBL12410766 | 0.82 | MAPT (0.46) | MAPTRECQLMEN1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699427-B1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AG (DE) | 2008-02-27 | — | — | EP | claimed |
| US-7244278-B2 | Agent and method for oxidative coloring of keratin fibers | WELLA AG (DE) | 2007-07-17 | — | — | US | claimed |
| US-20070067927-A1 | Agent and method for oxidative coloring of keratin fibers | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2007-03-29 | — | — | US | claimed |
| EP-1699427-A1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2006-09-13 | — | — | EP | claimed |
| WO-2005060928-A1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2005-07-07 | — | — | WO | claimed |
| EP-1699427-B1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AG (DE) | 2008-02-27 | — | — | EP | disclosed |
| US-7244278-B2 | Agent and method for oxidative coloring of keratin fibers | WELLA AG (DE) | 2007-07-17 | — | — | US | disclosed |
| US-20070067927-A1 | Agent and method for oxidative coloring of keratin fibers | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2007-03-29 | — | — | US | disclosed |
| EP-1699427-A1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005060928-A1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070067927-A1 | Agent and method for oxidative coloring of keratin fibers | KRT18, KIT, AOC1 | SLC6A2 4770/4885SLC6A3 4863/4885MAPT 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.