Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | BCR | P11274 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 6/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574839 | 0.98 | ABL1 (0.56) | ABL1ABCB1BCRESR2BCL2L1 | |
| SCHEMBL28881713 | 0.89 | ABL1 (0.57) | ABL1ABCB1BCRESR2BCL2L1 | |
| Bromide SCHEMBL3136378 | 0.81 | ABL1 (0.44) | ABL1ABCB1BCRESR2BCL2L1 | |
| Trifluoromethanesulfonic Acid SCHEMBL4288971 | 0.80 | PTPN1 (0.41) | ABL1ABCB1BCRESR2BCL2L1 | |
| SCHEMBL1649339 | 0.80 | ABL1 (0.76) | ABL1ABCB1BCRESR2BCL2L1 | |
| SCHEMBL4432976 | 0.80 | ABL1 (0.76) | ABL1ABCB1BCRESR2BCL2L1 | |
| SCHEMBL502109 | 0.78 | ABL1 (0.45) | ABL1ABCB1BCRESR2BCL2L1 | |
| SCHEMBL12609346 | 0.78 | ALDH1A1 (0.47) | BCL2L1MMP3PTPN1BACE1MEN1 | |
| SCHEMBL22931425 | 0.78 | IDO1 (0.38) | ABL1ABCB1BCRESR2BCL2L1 | |
| SCHEMBL1885427 | 0.78 | ABL1 (0.73) | ABL1ABCB1BCRESR2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915360-A2 | PHOTOACTIVE COMPOUNDS | AZ Electronic Materials USA Corp. (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007007175-A2 | PHOTOACTIVE COMPOUNDS | AZ ELECTRONIC MATERIAL USA CORP. (DE) | 2007-01-18 | — | — | WO | disclosed |