Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piridronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 14/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piridronic Acid SCHEMBL223779 | 0.83 | FDPS (1.00) | FDPSPTPRAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL10622087 | 0.76 | FDPS (0.71) | FDPSLMNAHRH1 | |
| Piridronic Acid SCHEMBL634964 | 0.74 | FDPS (0.79) | FDPSPTPRAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL1904611 | 0.73 | FDPS (1.00) | FDPSPDE3A | |
| SCHEMBL8712700 | 0.71 | FDPS (0.97) | FDPSPDE3A | |
| SCHEMBL8712686 | 0.71 | FDPS (0.97) | FDPSPDE3A | |
| SCHEMBL7165923 | 0.70 | FDPS (0.65) | FDPSLMNA | |
| SCHEMBL9554186 | 0.70 | FDPS (0.65) | FDPS | |
| SCHEMBL8165506 | 0.69 | FDPS (0.70) | FDPSPTPRAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL9074140 | 0.68 | FDPS (0.68) | FDPSLMNAPTPRAHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446115-B1 | CYANOALKYLAMINO DERIVATIVES AS PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-02-27 | — | — | EP | claimed |