Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29219582 | 0.93 | TSHR (0.34) | CES1ANPEP | |
| SCHEMBL170051 | 0.89 | — | — | |
| SCHEMBL4861420 | 0.86 | THRB (0.44) | CA12CA1CA2CA9HTT | |
| SCHEMBL187351 | 0.86 | THRB (0.44) | CA12CA1CA2CA9HTT | |
| SCHEMBL5715855 | 0.86 | THRB (0.44) | CA12CA1CA2CA9HTT | |
| SCHEMBL23302194 | 0.86 | THRB (0.44) | CA12CA1CA2CA9HTT | |
| Ammonia Solution, Strong SCHEMBL2792661 | 0.86 | CA12 (0.39) | CA12CA1CA2CA9HTT | |
| SCHEMBL4190029 | 0.86 | THRB (0.44) | CA12CA1CA2CA9HTT | |
| Ammonia Solution, Strong SCHEMBL2792659 | 0.86 | CA12 (0.39) | CA12CA1CA2CA9HTT | |
| SCHEMBL2338285 | 0.86 | THRB (0.44) | CA12CA1CA2CA9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116813890-A | Method for synthesizing conjugated polymer by using Suzuki-Miyaura catalytic polymerization system and application thereof | 中国科学院大学 | 2023-09-29 | — | — | CN | claimed |
| CN-117924258-A | Pyridone compound derivative and application thereof | 复旦大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-112313208-B | Bicyclic carboxamides and methods of use thereof | 泰普斯特医疗公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117820094-A | Method for coupling organic boron and electrophile with participation of ferric chloride | 吉林大学 | 2024-04-05 | — | — | CN | disclosed |
| CN-117417373-A | Ionic difluoromethyl copper (I) complex, synthesis method and application thereof | 中国科学院上海有机化学研究所 | 2024-01-19 | — | — | CN | disclosed |
| CN-117157286-A | Pyridyl-substituted oxo-isoindoline compounds | 百时美施贵宝公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-116813890-A | Method for synthesizing conjugated polymer by using Suzuki-Miyaura catalytic polymerization system and application thereof | 中国科学院大学 | 2023-09-29 | — | — | CN | disclosed |
| CN-116813890-A | Method for synthesizing conjugated polymer by using Suzuki-Miyaura catalytic polymerization system and application thereof | 中国科学院大学 | 2023-09-29 | — | — | CN | disclosed |
| CN-116283768-A | Preparation method of aryl acridine compound | 西安凯翔生物医药科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-115490715-A | Method for preparing aryl boronic acid pinacol ester compound by taking phenol as raw material | 遵义医科大学 | 2022-12-20 | — | — | CN | disclosed |
| CN-113527275-A | SKLB1039 compound and preparation method and application thereof | 成都师范学院 | 2021-10-22 | — | — | CN | disclosed |
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | disclosed |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-29 | — | — | US | disclosed |
| CN-102648174-A | Novel arylated camphenes, process for their preparation and their use | YISSUM RES DEV CO (IL) | 2012-08-22 | — | — | CN | disclosed |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | US | disclosed |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | US | disclosed |
| US-7429596-B2 | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-30 | — | — | US | disclosed |
| CN-101018552-A | Intracellular receptor modulator compounds and methods | LIGAND PHARM INC (US) | 2007-08-15 | — | — | CN | disclosed |
| US-20050085472-A1 | Pyrazolo pyrimidine derivatives and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-04-21 | — | — | US | disclosed |
| WO-2005007085-A2 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085472-A1 | Pyrazolo pyrimidine derivatives and methods of use thereof | DPYD, DHODH, DLD | CES1 997/4885CA12 4808/4885CA1 4544/4885 |
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, DHODH, DLD | CES1 997/4885CA12 4808/4885CA1 4544/4885 |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, DHODH, DLD | CES1 997/4885CA12 4808/4885CA1 4544/4885 |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | DPYD, DHODH, DLD | CES1 997/4885CA12 4808/4885CA1 4544/4885 |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | DPYD, DHODH, DLD | CES1 997/4885CA12 4808/4885CA1 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.