Dyrene

Dyrene

SCHEMBL4614742

CCNc1nc(Cl)nc(NC(C)C)n1.Clc1nc(Cl)nc(Nc2ccccc2Cl)n1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.60
GAA P10253 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
LMNA P02545 1/20 0.47
POLB P06746 2/20 0.47
KCNH3 Q9ULD8 2/20 0.44
ALDH1A1 P00352 2/20 0.44
GBA1 P04062 1/20 0.44
TP53 P04637 1/20 0.44
ALOX15 P16050 1/20 0.44
MAPK1 P28482 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
SIRT5 Q9NXA8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dyrene SCHEMBL9749781 0.92 TSHR (0.51) TSHRGAATDP1LMNAPOLB
Dyrene SCHEMBL9749815 0.91 TSHR (0.73) TSHRGAATDP1LMNAALDH1A1
Atrazine SCHEMBL29353679 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Atrazine SCHEMBL20723465 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Propazine SCHEMBL9092745 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Atrazine SCHEMBL1516439 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Atrazine SCHEMBL9117361 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Atrazine SCHEMBL4306269 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Propazine SCHEMBL29366712 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB
Atrazine SCHEMBL36936 0.81 GAA (0.73) TSHRGAATDP1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1408756-B1 WEED CONTROL PROCESS SYNGENTA LTD (GB) 2008-01-23 EP claimed
US-5573922-A COMPETITIVE POLYCLONAL ANTIBODY BINDING, TESTING WATER SAMPLES BOEHRINGER MANNHEIM GMBH (DE) 1996-11-12 US claimed
EP-0089268-B1 THIOLCARBAMATE-TRIAZINE LIQUID HERBICIDE COMPOSITION STAUFFER CHEMICAL COMPANY (US) 1986-07-02 EP claimed
CN-112778227-B Method for detoxifying atrazine triazine herbicide under alkaline condition 南昌航空大学 2022-08-02 CN disclosed
CN-112778227-B Method for detoxifying atrazine triazine herbicide under alkaline condition 南昌航空大学 2022-08-02 CN disclosed
CN-112778227-B Method for detoxifying atrazine triazine herbicide under alkaline condition 南昌航空大学 2022-08-02 CN disclosed
CN-113287616-B Weeding composition containing atrazine, mesotrione and bialaphos and application thereof 广西壮族自治区农业科学院 2021-11-12 CN disclosed
CN-113287616-A Weeding composition containing atrazine, mesotrione and bialaphos and application thereof 广西壮族自治区农业科学院 2021-08-24 CN disclosed
CN-112778227-A Method for detoxifying atrazine triazine herbicide under alkaline condition 南昌航空大学 2021-05-11 CN disclosed
CN-112778227-A Method for detoxifying atrazine triazine herbicide under alkaline condition 南昌航空大学 2021-05-11 CN disclosed
CN-112778227-A Method for detoxifying atrazine triazine herbicide under alkaline condition 南昌航空大学 2021-05-11 CN disclosed
US-5683961-A CONSISTS OF A MONOCARBOXYLIC ACID OR SALT AND A HERBICIDE SELECTED FROM THE GROUP CONSISTING OF BIPYRIDILLIUM COMPOUNDS AND DIPHENYL ETHER ACIDS OR SALTS MYCOGEN CORPORATION (US) 1997-11-04 US disclosed
US-5683962-A SYNERGISTIC MIXTURE OF FATTY ACID AND PYRAZON MYCOGEN CORPORATION (US) 1997-11-04 US disclosed
US-5683959-A MIXTURE OF A MONOCARBOXYLIC ACID OR SALT THEREOF AND GLUFOSINATE MYCOGEN CORPORATION (US) 1997-11-04 US disclosed
US-5681792-A FATTY ACID, HERBICIDE SYNERGISTIC MIXTURE MYCOGEN CORPORATION (US) 1997-10-28 US disclosed
CN-1086956-A Herbicide-Caojinjing for sugarcane land LIANG QIONG (CN) 1994-05-25 CN disclosed
US-5284819-A Weed control MYCOGEN CORPORATION (US) 1994-02-08 US disclosed
US-5196044-A Fatty acid and glyphosate herbicide MYCOGEN CORPORATION (US) 1993-03-23 US disclosed
US-4824475-A CONTAINING GLYCOL SULFONATE OR SULFAMATE THE DOW CHEMICAL COMPANY (US) 1989-04-25 US disclosed
EP-0081351-A1 Herbicidal triazinyl compositions with an epoxy butane and method of using THE DOW CHEMICAL COMPANY (US) 1983-06-15 EP disclosed