Dyrene

Dyrene

SCHEMBL9749781

CCNc1nc(NC(C)C)nc(SC)n1.Clc1nc(Cl)nc(Nc2ccccc2Cl)n1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.51
LMNA P02545 2/20 0.42
ALDH1A1 P00352 2/20 0.42
POLB P06746 2/20 0.41
MAPT P10636 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
HTT P42858 1/20 0.41
GAA P10253 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
GBA1 P04062 1/20 0.39
TP53 P04637 1/20 0.39
ALOX15 P16050 1/20 0.39
MAPK1 P28482 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
SIRT5 Q9NXA8 1/20 0.39
KCNH3 Q9ULD8 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dyrene SCHEMBL4614742 0.92 TSHR (0.60) TSHRLMNAALDH1A1POLBMAPT
Dyrene SCHEMBL9749815 0.84 TSHR (0.73) TSHRLMNAALDH1A1MAPTGAA
Prometryn SCHEMBL29456674 0.84 GAA (0.58) TSHRLMNAALDH1A1POLBMAPT
Ametryne SCHEMBL8812043 0.84 GAA (0.58) TSHRLMNAALDH1A1POLBMAPT
Prometryn SCHEMBL10969844 0.84 GAA (0.58) TSHRLMNAALDH1A1POLBMAPT
Propazine SCHEMBL11251019 0.84 GAA (0.58) TSHRLMNAALDH1A1POLBMAPT
Ametryne SCHEMBL31093673 0.84 GAA (0.58) TSHRLMNAALDH1A1POLBMAPT
Ametryne SCHEMBL8541067 0.77 POLB (0.54) TSHRLMNAALDH1A1POLBMAPT
Prometryn SCHEMBL7945620 0.77 POLB (0.54) TSHRLMNAALDH1A1POLBMAPT
Ametryne SCHEMBL65196 0.77 POLB (0.54) TSHRLMNAALDH1A1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5100776-A Forming antigen coupled carrier matrix sensitive to triazine herbicides, immunizing animals to obtain antibodies DR. PFEIFFER BIOANALYTIK KG (DE) 1992-03-31 US disclosed