Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27878117 | 0.78 | — | — | |
| SCHEMBL25443755 | 0.77 | MAPT (0.50) | ADRA2AL3MBTL1POLBTSHRNPSR1 | |
| SCHEMBL27515091 | 0.74 | CYP1A2 (0.40) | ADRA2AL3MBTL1NPSR1CYP1A2CYP2C9 | |
| SCHEMBL4893047 | 0.73 | ABL1 (0.42) | ADRA2ATSHRNPSR1CYP1A2CYP2C9 | |
| SCHEMBL28189161 | 0.73 | — | — | |
| SCHEMBL1548538 | 0.71 | ALDH1A1 (0.56) | ADRA2AL3MBTL1TSHRHSD17B10CYP1A2 | |
| SCHEMBL183639 | 0.69 | MAPT (0.67) | ADRA2AL3MBTL1POLBHSD17B10ADORA2A | |
| SCHEMBL26000374 | 0.69 | MEN1 (0.47) | ADRA2AL3MBTL1POLBNPSR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL17710410 | 0.69 | ALDH1A1 (0.54) | ADRA2AL3MBTL1TSHRNPSR1HSD17B10 | |
| SCHEMBL27636205 | 0.69 | GAA (0.47) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910358-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | Astellas Pharma Inc. (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |