Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252528 | 0.77 | GAA (0.70) | GAAHTTALDH1A1THRB | |
| SCHEMBL27878117 | 0.74 | — | — | |
| SCHEMBL141474 | 0.71 | GAA (0.58) | GAAHTTALDH1A1THRB | |
| SCHEMBL6554127 | 0.71 | GAA (0.58) | GAAHTTALDH1A1THRB | |
| SCHEMBL27515091 | 0.71 | CYP1A2 (0.40) | ALDH1A1 | |
| SCHEMBL11252585 | 0.69 | HTT (0.61) | GAAHTTALDH1A1THRB | |
| SCHEMBL5028293 | 0.69 | GAA (0.61) | GAAHTTALDH1A1THRB | |
| SCHEMBL4615070 | 0.69 | ADRA2A (0.41) | GAAALDH1A1 | |
| SCHEMBL28189161 | 0.69 | — | — | |
| SCHEMBL6161907 | 0.68 | THRB (0.66) | GAAHTTALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1832925-B | New P2X7 receptor avtagonists and their use | ASTRAZENECA AB | 2010-05-05 | — | — | CN | disclosed |
| CN-101111488-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-01-23 | — | — | CN | disclosed |
| CN-1832925-A | New p2x7 receptor avtagonists and their use | ASTRAZENECA AB (SE) | 2006-09-13 | — | — | CN | disclosed |