Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.69 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.69 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.69 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.69 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.69 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.69 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.69 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.69 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.69 |
| ▸ | CNR1 | P21554 | 8/20 | 0.69 |
| ▸ | CNR2 | P34972 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814988 | 0.98 | CNR1 (0.71) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| Hydrochloric Acid SCHEMBL4602562 | 0.98 | CNR1 (0.71) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL4615838 | 0.94 | CNR1 (0.69) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL3813720 | 0.90 | CNR1 (0.74) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL4614866 | 0.90 | CNR1 (0.69) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| Hydrochloric Acid SCHEMBL4604024 | 0.90 | CNR1 (0.74) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL4614931 | 0.89 | CNR1 (0.68) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL3814159 | 0.89 | CNR1 (0.72) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL4611065 | 0.89 | CNR1 (0.73) | CNR1CNR2CYP2C9GPR55ABCC4 | |
| SCHEMBL4831846 | 0.88 | CNR1 (0.71) | CNR1CNR2CYP2C9GPR55ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915364-A1 | PYRAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | claimed |
| WO-2007020388-A1 | PYRAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | claimed |
| EP-1915364-A1 | PYRAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007020388-A1 | PYRAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |