Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1530124 | 0.85 | CYP3A4 (0.48) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL584314 | 0.84 | ALDH1A1 (0.59) | ALDH1A1GAAVCAM1LMNAMEN1 | |
| SCHEMBL27183377 | 0.84 | ALDH1A1 (0.58) | ALDH1A1GAAVCAM1LMNAMEN1 | |
| SCHEMBL14964656 | 0.81 | ALDH1A1 (0.55) | ALDH1A1GAAVCAM1LMNAMEN1 | |
| SCHEMBL4901044 | 0.81 | ALDH1A1 (0.73) | ALDH1A1GAAVCAM1LMNAMEN1 | |
| SCHEMBL5499416 | 0.81 | CA12 (0.54) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL18687305 | 0.81 | PARP1 (0.44) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL1530093 | 0.81 | VCAM1 (0.56) | ALDH1A1GAAVCAM1LMNAMEN1 | |
| SCHEMBL5625355 | 0.81 | FFAR4 (0.65) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL6200524 | 0.80 | ALDH1A1 (0.54) | ALDH1A1GAAVCAM1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |
| EP-0863142-A1 | Heterocyclic herbicides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0496595-B1 | Aniline derivatives and process for producing the same | NISSAN CHEMICAL IND LTD (JP) | 1995-09-06 | — | — | EP | disclosed |
| US-5416236-A | Sulfonylation, reduction and carbamylation in multistage process | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-05-16 | — | — | US | disclosed |
| EP-0496595-A1 | Aniline derivatives and process for producing the same | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| EP-0069584-B1 | COLOR-FORMING SULFONAMIDODIPHENYLAMINES, PHOTOGRAPHIC ELEMENTS CONTAINING THEM AND CORRESPONDING PHENAZINE DYES | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-06-05 | — | — | EP | disclosed |
| EP-0069584-A1 | Color-forming sulfonamidodiphenylamines, photographic elements containing them and corresponding phenazine dyes | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1983-01-12 | — | — | EP | disclosed |