⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9307288 | 1.00 | DNM1 (0.44) | — | |
| SCHEMBL6614504 | 1.00 | DNM1 (0.44) | — | |
| SCHEMBL6682548 | 1.00 | DNM1 (0.44) | — | |
| Hydrochloric Acid SCHEMBL6023728 | 0.97 | DNM1 (0.42) | — | |
| SCHEMBL341868 | 0.97 | — | — | |
| SCHEMBL341549 | 0.88 | — | — | |
| Phosphonic Acid SCHEMBL8612224 | 0.82 | DNM1 (0.57) | — | |
| Phosphonic Acid SCHEMBL3029099 | 0.82 | DNM1 (0.57) | — | |
| SCHEMBL2519667 | 0.82 | — | — | |
| Butane SCHEMBL27839119 | 0.79 | DNM1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750724-A4 | METHOD FOR IMPROVING COGNITIVE FUNCTION BY CO-ADMINISTRATION OF A GABAB RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR | UNIV JOHNS HOPKINS (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1750724-A1 | METHOD FOR IMPROVING COGNITIVE FUNCTION BY CO-ADMINISTRATION OF A GABAB RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR | THE JOHNS-HOPKINS UNIVERSITY (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005112946-A1 | METHOD FOR IMPROVING COGNITIVE FUNCTION BY CO-ADMINISTRATION OF A GABAB RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR | THE JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | WO | disclosed |
| WO-2005112908-A1 | METHOD FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050267077-A1 | Method for improving cognitive function by co-administration of a GABAB receptor antagonist and an acetylcholinesterase inhibitor | JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | US | disclosed |
| US-20050267076-A1 | Method for improving cognitive function | JOHNS HOPKINS UNIVERSITY (US) | 2005-12-01 | — | — | US | disclosed |