SCHEMBL4616017

SCHEMBL4616017

CCCCCCCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.41
TSHR P16473 4/20 0.40
THRB P10828 1/20 0.40
LPAR2 Q9HBW0 3/20 0.32
LPAR3 Q9UBY5 3/20 0.32
DNM1 Q05193 5/20 0.32
ALDH1A1 P00352 3/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
HSD17B10 Q99714 1/20 0.32
SLC22A1 O15245 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4615188 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL4612625 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL4612788 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL4612489 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL946330 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL945866 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL4613469 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL4612616 1.00 LMNA (0.41) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL6152804 0.98 LMNA (0.39) LMNATSHRTHRBLPAR2LPAR3
SCHEMBL6152487 0.98 LMNA (0.39) LMNATSHRTHRBLPAR2LPAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1481660-B1 Cosmetic SHINETSU CHEMICAL CO (JP) 2008-02-20 EP disclosed
US-20040241126-A1 Cosmetic SHIN-ETSU CHEMICAL CO., LTD. (JP) 2004-12-02 US disclosed
EP-1481660-A1 Cosmetic Shin-Etsu Chemical Co., Ltd. (JP) 2004-12-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040241126-A1 Cosmetic SGMS1, ALG3, RIF1 LMNA 2493/4885TSHR 3023/4885THRB 3952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.