Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4615188 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL4612625 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL4612788 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL4612489 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL4616017 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL946330 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL4613469 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL4612616 | 1.00 | LMNA (0.41) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL6152804 | 0.98 | LMNA (0.39) | LMNATSHRTHRBLPAR2LPAR3 | |
| SCHEMBL6152487 | 0.98 | LMNA (0.39) | LMNATSHRTHRBLPAR2LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592547-B2 | Organopolysiloxane, a method of preparing the same and a cosmetic comprising the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2013-11-26 | — | — | US | disclosed |
| US-20110015337-A1 | ORGANOPOLYSILOXANE, A METHOD OF PREPARING THE SAME AND A COSMETIC COMPRISING THE SAME | SAKUTA KOJI | 2011-01-20 | — | — | US | disclosed |
| EP-2014701-B1 | Organopolysiloxane, a method of preparing the same and a cosmetic comprising the same | SHINETSU CHEMICAL CO (JP) | 2010-11-10 | — | — | EP | disclosed |
| EP-2014701-A2 | Organopolysiloxane, a method of preparing the same and a cosmetic comprising the same | Shin-Etsu Chemical Co., Ltd. (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-20080311060-A1 | Organopolysiloxane, a method of preparing the same and a cosmetic comprising the same | SHIN-ETSU CHEMICAL CO., LTD. | 2008-12-18 | — | — | US | disclosed |
| EP-1481660-B1 | Cosmetic | SHINETSU CHEMICAL CO (JP) | 2008-02-20 | — | — | EP | disclosed |
| EP-1481979-B1 | Preparation of branched tetrasiloxane | SHINETSU CHEMICAL CO (JP) | 2007-09-19 | — | — | EP | disclosed |
| EP-1510520-B1 | Preparation of branched siloxane | SHINETSU CHEMICAL CO (JP) | 2006-07-26 | — | — | EP | disclosed |
| US-6943264-B2 | Preparation of branched siloxane | SHIN-ETSU CHEMICAL, CO., LTD. (JP) | 2005-09-13 | — | — | US | disclosed |
| US-6875881-B2 | Preparation of branched tetrasiloxane | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |
| US-20050049427-A1 | Preparation of branched siloxane | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2005-03-03 | — | — | US | disclosed |
| EP-1510520-A1 | Preparation of branched siloxane | Shin-Etsu Chemical Co., Ltd. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040242912-A1 | Reactin disiloxane with alcohol in presence of acid catalyst | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| US-20040241126-A1 | Cosmetic | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| EP-1481660-A1 | Cosmetic | Shin-Etsu Chemical Co., Ltd. (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1481979-A1 | Preparation of branched tetrasiloxane | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2004-12-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040241126-A1 | Cosmetic | SGMS1, ALG3, RIF1 | LMNA 2493/4885TSHR 3023/4885THRB 3952/4885 |
| US-20080311060-A1 | Organopolysiloxane, a method of preparing the same and a cosmetic comprising the same | IDUA, PLOD3, PLOD2 | LMNA 1428/4885TSHR 2000/4885THRB 3880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.