Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905639 | 0.76 | SMN1; SMN2 (0.56) | CYP1A2CYP2C9CYP2C19SMYD3HTT | |
| SCHEMBL28596221 | 0.74 | SMN1; SMN2 (0.37) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL28596244 | 0.72 | KDM4E (0.38) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL1196464 | 0.72 | CYP19A1 (0.39) | POLBHTTRAB9ARXFP1KDM4E | |
| SCHEMBL5717534 | 0.71 | MAPT (0.59) | POLBHTTGLAKDM4EALDH1A1 | |
| SCHEMBL13749047 | 0.70 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL28609555 | 0.69 | ALDH1A1 (0.38) | CYP1A2CYP3A4CYP2C9CYP2C19GLA | |
| SCHEMBL28589922 | 0.69 | MAOB (0.42) | CYP1A2CYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL6759842 | 0.69 | CYP2A6 (0.47) | SMYD3KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1275821 | 0.65 | MAPT (0.64) | POLBALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |