SCHEMBL461648

SCHEMBL461648

O=C1C(O)=C(O)C(=O)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APAF1 O14727 2/20 1.00
TDP2 O95551 2/20 1.00
MEN1 O00255 6/20 0.65
KMT2A Q03164 6/20 0.65
CDC25B P30305 1/20 0.65
MAPT P10636 7/20 0.61
MAPK1 P28482 6/20 0.61
MAOA P21397 4/20 0.61
KDM4E B2RXH2 4/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
RECQL P46063 3/20 0.61
NPSR1 Q6W5P4 2/20 0.61
NPC1 O15118 2/20 0.61
RAB9A P51151 2/20 0.61
S100A4 P26447 2/20 0.61
CES2 O00748 1/20 0.61
TERT O14746 1/20 0.61
PLIN1 O60240 1/20 0.61
S1PR4 O95977 1/20 0.61
LMNA P02545 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29678361 1.00 APAF1 (1.00) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL20532817 0.94 APAF1 (0.89) APAF1TDP2MEN1KMT2ACDC25B
Bilawsone SCHEMBL3768549 0.86 APAF1 (0.75) APAF1TDP2MEN1KMT2ACDC25B
Bilawsone SCHEMBL30884954 0.86 APAF1 (0.75) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL29884321 0.86 APAF1 (0.75) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL6988547 0.86 APAF1 (0.75) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL31606781 0.82 APAF1 (0.68) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL10494196 0.82 P2RX7 (0.72) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL10068411 0.82 P2RX7 (0.72) APAF1TDP2MEN1KMT2ACDC25B
SCHEMBL29728498 0.82 APAF1 (0.68) APAF1TDP2MEN1KMT2ACDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 675 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3280402-B1 TOLAN COMPOUNDS FOR PROMOTING WOUND HEALING BIOMENDICS LLC (US) 2024-06-05 EP claimed
EP-3324951-B1 PERITONEAL THERAPEUTIC FLUID OPTERION HEALTH AG (CH) 2021-05-26 EP claimed
CN-110075307-A Peritoneal treatment liquid 奥普泰里翁健康股份公司 2019-08-02 CN claimed
CN-105158451-B Method of the pH/ ion concentration gradient to adjust bio-molecular interaction is generated near electrode surface 罗伯特·博世有限公司 2018-11-20 CN claimed
CN-107921009-A Peritoneal treating liquid 奥普泰里翁健康股份公司 2018-04-17 CN claimed
CN-107417508-A The method that molten-salt growth method synthesizes naphthazarin 云南中烟工业有限责任公司 2017-12-01 CN claimed
EP-3096735-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME Combe International Ltd. (US) 2016-11-30 EP claimed
CN-105916482-A Gradual hair color compositions and methods of use thereof 酷姆国际公司 2016-08-31 CN claimed
WO-2015112789-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME COMBE INTERNATIONAL LTD. (US) 2015-07-30 WO claimed
US-7741241-B2 Hydroprocessing catalyst, method for the preparation thereof and use of the same TOTAL RAFFINAGE MARKETING (FR) 2010-06-22 US claimed
US-20030172467-A1 Gradual permanent coloring of hair using dye intermediates dissolved in alkaline water with fatty alcohol UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-09-18 US claimed
US-20030154562-A1 Two step permanent coloring of hair UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-08-21 US claimed
US-20030154561-A1 Gradual permanent coloring of hair using dye intermediates in a shampoo base UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-08-21 US claimed
US-20030140428-A1 Gradual permanent coloring of hair using dye intermediates in a shampoo base UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-07-31 US claimed
US-20030074748-A1 Method and composition for the gradual permanent coloring of hair UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-04-24 US claimed
EP-0498707-B1 Process of dyeing keratinous fibers with a mono- or di-hydroxyindole and a non-oxidative aromatic carbonyl derivative and dyeing agent OREAL (FR) 1995-08-02 EP claimed
EP-0498707-A1 Process of dyeing keratinous fibers with a mono- or di-hydroxyindole and a non-oxidative aromatic carbonyl derivative and dyeing agent L'OREAL (FR) 1992-08-12 EP claimed
US-5064442-A HAIR DYES L'OREAL (FR) 1991-11-12 US claimed
US-4888026-A HAIR DYES; OXIDATION RESISTANCE L'OREAL (FR) 1989-12-19 US claimed
US-4425404-A MULTILAYER, PROTECTIVE COATINGS MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 1984-01-10 US claimed