SCHEMBL461708

SCHEMBL461708

CCCCCNc1cccc(C(N)=O)c1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 1/20 0.54
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
PARP1 P09874 9/20 0.51
PARP10 Q53GL7 3/20 0.51
F3 P13726 1/20 0.48
F2R P25116 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
PARP14 Q460N5 1/20 0.47
FAAH O00519 1/20 0.46
NAAA Q02083 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19665932 0.98 HDAC11 (0.54) HTR7MEN1KMT2AHDAC11HDAC8
SCHEMBL19665961 0.98 HDAC11 (0.54) HTR7MEN1KMT2AHDAC11HDAC8
SCHEMBL19710767 0.95 HTR7 (0.55) HTR7MEN1KMT2AHDAC11HDAC8
SCHEMBL18893559 0.89 MEN1 (0.54) HTR7MEN1KMT2APARP1PARP10
SCHEMBL7556750 0.87 HDAC11 (0.57) HDAC11HDAC8F2RSMN1; SMN2GAA
SCHEMBL9231035 0.86 NR1H4 (0.56) HDAC11HDAC8F2RNAAA
SCHEMBL6330053 0.85 HDAC11 (0.58) HDAC11HDAC8NAAA
SCHEMBL21940532 0.85 HDAC11 (0.58) HDAC11HDAC8NAAA
SCHEMBL11935020 0.85 HTR7 (0.54) HTR7MEN1KMT2AHDAC8PARP1
SCHEMBL30012465 0.85 HDAC11 (0.58) HDAC11HDAC8NAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964735-B2 Insecticidal 3-acylaminobenzanilides BAYER CROPSCIENCE AG (DE) 2011-06-21 US claimed
EP-2394986-B1 3-AMINOXALYLAMINOBENZAMIDE DERIVATIVES, AND INSECTICIDAL AND MITICIDAL AGENTS CONTAINING SAME AS ACTIVE INGREDIENT AGRO KANESHO CO LTD (JP) 2013-12-04 EP disclosed
US-8541473-B2 3-aminoxalyl-aminobenzamide derivatives and insecticidal and miticidal agents containing same as active ingredient AGRO-KANESHO CO., LTD. (JP) 2013-09-24 US disclosed
US-20120022263-A1 3-AMINOXALYL-AMINOBENZAMIDE DERIVATIVES AND INSECTICIDAL AND MITICIDAL AGENTS CONTAINING SAME AS ACTIVE INGREDIENT AGRO-KANESHO CO., LTD. (JP) 2012-01-26 US disclosed
EP-2394986-A1 3-AMINOXALYLAMINOBENZAMIDE DERIVATIVES, AND INSECTICIDAL AND MITICIDAL AGENTS CONTAINING SAME AS ACTIVE INGREDIENT Agro-Kanesho Co., Ltd. (JP) 2011-12-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120022263-A1 3-AMINOXALYL-AMINOBENZAMIDE DERIVATIVES AND INSECTICIDAL AND MITICIDAL AGENTS CONTAINING SAME AS ACTIVE INGREDIENT HDHD5, CBR3, BAK1 HTR7 664/4885MEN1 1004/4885KMT2A 227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.