SCHEMBL4617474

SCHEMBL4617474

Cc1ccc(C(=C2CCCC(C)(C)C2(C)C)c2ccccc2)cc1OCCCC(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.49
ALDH1A1 P00352 3/20 0.42
HTT P42858 2/20 0.42
KDM4E B2RXH2 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
PPARA Q07869 6/20 0.41
PPARG P37231 5/20 0.41
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
RXRA P19793 1/20 0.36
S1PR5 Q9H228 1/20 0.36
TTR P02766 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C8 P10632 1/20 0.35
CHRM1 P11229 1/20 0.35
CYP2C9 P11712 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SLCO1B3 Q9NPD5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3078835 0.77 TSHR (0.53) TSHRALDH1A1HTTKDM4EL3MBTL1
SCHEMBL3161533 0.68 TSHR (1.00) TSHRALDH1A1HTTKDM4EL3MBTL1
SCHEMBL8752667 0.67 TSHR (0.68) TSHRL3MBTL1PPARAPPARGMEN1
SCHEMBL503565 0.65 TSHR (0.74) TSHRALDH1A1KDM4EPPARAPPARG
SCHEMBL3074996 0.65 PTGDR2 (0.44) TSHRKDM4EL3MBTL1PPARAPPARG
SCHEMBL3078288 0.65 APOBEC3A (0.39) TSHRALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL28066250 0.65 TSHR (0.90) TSHRALDH1A1HTTKDM4EL3MBTL1
SCHEMBL3085602 0.64 ALDH1A1 (0.36) TSHRALDH1A1HTTKDM4EL3MBTL1
SCHEMBL3043854 0.63 TSHR (0.61) TSHRALDH1A1HTTKDM4EL3MBTL1
SCHEMBL3727479 0.63 TSHR (0.87) TSHRALDH1A1HTTKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1891026-A2 CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS Smithkline Beecham Corporation (US) 2008-02-27 EP disclosed
WO-2006127871-A2 CYCLOALKYLIDENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2006-11-30 WO disclosed