Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22782667 | 0.98 | TSHR (0.59) | TSHRLMNATDP1ALDH1A1MEN1 | |
| SCHEMBL8355272 | 0.98 | TSHR (0.59) | TSHRLMNATDP1ALDH1A1MEN1 | |
| SCHEMBL8752667 | 0.95 | TSHR (0.68) | TSHRLMNATDP1MEN1KMT2A | |
| SCHEMBL3046950 | 0.89 | LMNA (0.69) | TSHRLMNATDP1ALDH1A1MEN1 | |
| SCHEMBL8151680 | 0.85 | LMNA (0.62) | LMNAALDH1A1MEN1KMT2APPARA | |
| SCHEMBL8162525 | 0.85 | LMNA (0.62) | LMNAALDH1A1MEN1KMT2APPARA | |
| SCHEMBL8158709 | 0.85 | LMNA (0.62) | LMNAALDH1A1MEN1KMT2APPARA | |
| SCHEMBL8163174 | 0.85 | LMNA (0.62) | LMNAALDH1A1MEN1KMT2APPARA | |
| SCHEMBL8148742 | 0.85 | LMNA (0.62) | LMNAALDH1A1MEN1KMT2APPARA | |
| SCHEMBL8161670 | 0.85 | LMNA (0.62) | LMNAALDH1A1MEN1KMT2APPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470861-B2 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER (US) | 2013-06-25 | — | — | US | claimed |
| US-8470861-B2 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER | 2010-07-01 | — | — | US | disclosed |
| US-7196080-B2 | Respiratory system disordeers; chronic obstructive pulminary disease | ASTELLAS PHARMA INC. (JP) | 2007-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | TXNRD2, HADHA, PRDX5 | TSHR 4649/4885LMNA 2194/4885TDP1 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.