Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6102307 | 0.91 | SFRP1 (0.60) | SFRP1CA12CA1CA2CA14 | |
| SCHEMBL4617383 | 0.84 | SFRP1 (0.69) | SFRP1CA12CA1CA2CA14 | |
| SCHEMBL6104080 | 0.84 | ALDH1A1 (0.52) | SFRP1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6103669 | 0.84 | MAPT (0.52) | SFRP1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4616128 | 0.83 | SFRP1 (0.61) | SFRP1CA12CA1CA2CA14 | |
| SCHEMBL4619015 | 0.83 | SFRP1 (0.51) | SFRP1ALDH1A1HTR6MAPTSMN1; SMN2 | |
| SCHEMBL6102647 | 0.83 | SFRP1 (0.64) | SFRP1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4618510 | 0.82 | ALDH1A1 (0.76) | SFRP1CA12CA1CA2CA14 | |
| SCHEMBL4619170 | 0.82 | SFRP1 (0.59) | SFRP1CA12CA1CA2CA14 | |
| SCHEMBL4617783 | 0.81 | SFRP1 (0.61) | SFRP1MAPTSMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |