Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909323 | 0.78 | CDC25A (0.38) | HTR6HPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL25176054 | 0.75 | PTPRC (0.44) | HTR6HPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL7633782 | 0.75 | ALDH1A1 (0.41) | HPGDALDH1A1CYP1A2MAPTMEN1 | |
| SCHEMBL7614983 | 0.74 | HTR6 (0.34) | HTR6MAOAMAOB | |
| SCHEMBL27447443 | 0.72 | KMT2A (0.43) | HPGDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL31072334 | 0.70 | ALDH1A1 (0.35) | HTR6L3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL276263 | 0.70 | HTR6 (0.40) | HTR6HPGDL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL20219170 | 0.70 | HTR6 (0.32) | HTR6 | |
| SCHEMBL16969052 | 0.70 | HTR6 (0.37) | HTR6HPGDL3MBTL1CES1MAOA | |
| SCHEMBL1906828 | 0.69 | MAPT (0.33) | HPGDL3MBTL1ALDH1A1CYP1A2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583530-A4 | 2-AMINOTHIAZOLE ALLOSTERIC ENHANCERS OF A1-ADENOSINE RECEPTORS | UNIV VIRGINIA (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1583530-A1 | 2-AMINOTHIAZOLE ALLOSTERIC ENHANCERS OF A1-ADENOSINE RECEPTORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2005-10-12 | — | — | EP | disclosed |
| WO-2003061655-A1 | 2-AMINOTHIAZOLE ALLOSTERIC ENHANCERS OF A1 ADENOSINE RECEPTORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2003-07-31 | — | — | WO | disclosed |