SCHEMBL461879

SCHEMBL461879

Cc1nc(C(N)=O)c(Cc2cc(-c3cnc4[nH]ncc4c3)cc3[nH]nc(F)c23)o1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3C3 Q8NEB9 3/20 0.34
BTK Q06187 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL470147 0.78 PIK3C3 (0.37) PIK3C3BTK
SCHEMBL12577375 0.67 PIK3C3 (0.37) PIK3C3BTK
SCHEMBL1960815 0.66 ROCK2 (0.43)
SCHEMBL456978 0.64 PIK3C3 (0.39) PIK3C3
SCHEMBL457168 0.64 PIK3CD (0.45) PIK3C3
SCHEMBL31008786 0.60 FBP1 (0.39)
SCHEMBL18426012 0.57 PIK3C3 (0.50) PIK3C3BTK
SCHEMBL29511927 0.57 NAMPT (0.44) PIK3C3BTK
SCHEMBL160863 0.57 NAMPT (0.44) PIK3C3BTK
SCHEMBL15296406 0.56 BTK (0.55) PIK3C3BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2613781-A1 INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION GlaxoSmithKline Intellectual Property Development Limited (GB) 2013-07-17 EP disclosed
WO-2012032065-A1 INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION GLAXO GROUP LIMITED (GB) 2012-03-15 WO disclosed