Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30493209 | 1.00 | TDP1 (0.52) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL30493185 | 0.88 | TDP1 (0.44) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL358770 | 0.86 | TDP1 (0.61) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL25161887 | 0.81 | TDP1 (0.55) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL2088309 | 0.81 | TDP1 (0.71) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL31119224 | 0.81 | TDP1 (0.71) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL31119225 | 0.81 | TDP1 (0.71) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL1755968 | 0.79 | TDP1 (0.53) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL4564308 | 0.79 | TSHR (0.60) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL3721283 | 0.78 | MAPT (0.57) | TDP1ALDH1A1L3MBTL1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103649263-B | Direct trifluoromethylation using trifluoromethane | 南加州大学 | 2016-06-29 | — | — | CN | claimed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | claimed |
| CN-103649263-A | Direct trifluoromethylation using trifluoromethane | UNIV SOUTHERN CALIFORNIA | 2014-03-19 | — | — | CN | claimed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | claimed |
| WO-2012148772-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-11-01 | — | — | WO | claimed |
| CN-116284040-B | Nitrogen-containing heterocyclic compound and medical application thereof | 华润医药研究院（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-116284040-A | Nitrogen-containing heterocyclic compound and medical application thereof | 华润医药研究院（深圳）有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-103649263-B | Direct trifluoromethylation using trifluoromethane | 南加州大学 | 2016-06-29 | — | — | CN | disclosed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| CN-103649263-A | Direct trifluoromethylation using trifluoromethane | UNIV SOUTHERN CALIFORNIA | 2014-03-19 | — | — | CN | disclosed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2012148772-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-11-01 | — | — | WO | disclosed |
| US-20080194552-A1 | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
| EP-1893605-A2 | SAMINOPYRIMIDINE DERIVATES WITH TIE2 INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006103449-A2 | SAMINOPYRIMIDINE DERIVATES WITH TIE2 INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194552-A1 | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity | TIE1, TEK, FLT1 | TDP1 2219/4885ALDH1A1 1756/4885L3MBTL1 3548/4885 |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | TST, FLI1, CYP2F1 | TDP1 3590/4885ALDH1A1 1358/4885L3MBTL1 1917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.