SCHEMBL4619436 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	NR1H4	Q96RI1	1/20	0.50

▸	CAPNS1	P04632	2/20	0.38

▸	CAPN1	P07384	2/20	0.38

▸	CASP3	P42574	11/20	0.33

▸	CASP1	P29466	10/20	0.33

▸	CASP7	P55210	10/20	0.33

▸	CASP6	P55212	10/20	0.33

▸	CASP8	Q14790	10/20	0.33

▸	ALDH1A1	P00352	1/20	0.33

▸	ELANE	P08246	1/20	0.32

▸	CTSD	P07339	3/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5709130	0.96	NR1H4 (0.55)	NR1H4CAPNS1CAPN1CASP3CASP1
SCHEMBL6989461	0.94	NR1H4 (0.51)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL4598052	0.94	NR1H4 (0.51)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL3834784	0.92	NR1H4 (0.50)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL14677996	0.92	NR1H4 (0.48)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL5706907	0.91	NR1H4 (0.49)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL3831703	0.91	NR1H4 (0.51)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL3838373	0.91	NR1H4 (0.50)	NR1H4CAPNS1CAPN1ELANECTSD
SCHEMBL6026583	0.91	NR1H4 (0.47)	NR1H4CAPNS1CAPN1CASP3CASP1
SCHEMBL4598195	0.91	NR1H4 (0.50)	NR1H4CAPNS1CAPN1ELANECTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1885694-A2	4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES	Microbia, Inc. (US)	2008-02-13	—	—	EP	disclosed
WO-2006124713-A2	4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES	MICROBIA, INC. (US)	2006-11-23	—	—	WO	disclosed