SCHEMBL4619864

SCHEMBL4619864

CSc1nc2ncc(C)cc2s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
KEAP1 Q14145 1/20 0.40
KDM4E B2RXH2 1/20 0.37
PKM P14618 2/20 0.36
CCR1 P32246 1/20 0.34
CCR5 P51681 1/20 0.34
CCR8 P51685 1/20 0.34
KDR P35968 1/20 0.34
AADAT Q8N5Z0 3/20 0.33
GRM1 Q13255 1/20 0.33
PARP10 Q53GL7 1/20 0.33
PARP2 Q9UGN5 1/20 0.33
F2RL3 Q96RI0 1/20 0.32
RAB9A P51151 2/20 0.32
CYP1A2 P05177 1/20 0.32
ALDH1A1 P00352 2/20 0.32
LMNA P02545 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6339430 0.81 HRH3 (0.40) SMN1; SMN2NPSR1KEAP1PKMKDR
SCHEMBL20489478 0.81 SMN1; SMN2 (0.39) SMN1; SMN2NPSR1KEAP1KDM4EPKM
SCHEMBL6336941 0.81 SMN1; SMN2 (0.50) SMN1; SMN2NPSR1KEAP1KDM4EPKM
SCHEMBL14858349 0.78 SMN1; SMN2 (0.41) SMN1; SMN2NPSR1KEAP1PKMKDR
SCHEMBL14858622 0.78 SMN1; SMN2 (0.37) SMN1; SMN2NPSR1KEAP1KDM4EPKM
SCHEMBL7912720 0.77 SMN1; SMN2 (0.43) SMN1; SMN2KDM4EPKMCCR1CCR5
SCHEMBL16421138 0.77 PKM (0.39) SMN1; SMN2NPSR1KEAP1KDM4EPKM
SCHEMBL21206885 0.77 HRH3 (0.43) SMN1; SMN2NPSR1KEAP1KDM4EPKM
SCHEMBL20489612 0.76 MGAM (0.37) SMN1; SMN2NPSR1KEAP1KDM4EPKM
SCHEMBL20489420 0.76 AADAT (0.38) SMN1; SMN2NPSR1KEAP1PKMKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080124732-A1 METHOD FOR OPTICAL MEASUREMENT OF MULTI-STRANDED NUCLEIC ACID FUJIFILM CORPORATION 2008-05-29 US disclosed
EP-1889880-A2 Method for optical measurement of multi-stranded nucleic acid FUJIFILM Corporation (JP) 2008-02-20 EP disclosed
EP-1362894-B1 Method for optical measurement of multi-stranded nucleic acid using cyanine dyes FUJIFILM CORP (JP) 2007-12-19 EP disclosed
US-20050112770-A1 Method for optical measurement of multi-stranded nucleic acid FUJI PHOTO FILM CO., LTD. 2005-05-26 US disclosed
EP-1362894-A2 Method for optical measurement of multi-stranded nucleic acid using cyanine dyes FUJI PHOTO FILM CO., LTD. (JP) 2003-11-19 EP disclosed