Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.68 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27422728 | 0.98 | KEAP1 (0.66) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL1850878 | 0.83 | KEAP1 (0.66) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL1850881 | 0.83 | KEAP1 (0.66) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL2062807 | 0.82 | KEAP1 (0.70) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL522945 | 0.82 | KEAP1 (0.70) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL1234889 | 0.82 | KEAP1 (0.70) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL8471924 | 0.82 | KEAP1 (0.56) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL4889937 | 0.81 | KEAP1 (0.74) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL2062949 | 0.81 | KEAP1 (1.00) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL415801 | 0.81 | KEAP1 (1.00) | KEAP1NFE2L2CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888525-A1 | 3,6-DISUBSTITUTED AZABICYCLO [3.1.0]HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | Ranbaxy Laboratories Limited (IN) | 2008-02-20 | — | — | EP | claimed |
| WO-2006117754-A1 | 3,6-DISUBSTITUTED AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-11-09 | — | — | WO | claimed |
| CN-100519526-C | Azabicyclo derivatives as muscarinic receptor antagonists | RANBAXY LAB LTD (IN) | 2009-07-29 | — | — | CN | disclosed |
| CN-1681784-A | Azabicyclo derivatives as muscarinic receptor antagonists | RANBAXY LAB LTD (IN) | 2005-10-12 | — | — | CN | disclosed |