Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355804 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL1612049 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL31441011 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL739759 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL1610352 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL29731284 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL14812708 | 0.81 | CES1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL8911138 | 0.79 | GRM5 (0.56) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL2720506 | 0.78 | ALDH1A1 (0.70) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL11818178 | 0.76 | SRD5A2 (0.55) | SMN1; SMN2NPC1RAB9AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |