Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CDYL2 | Q8N8U2 | 3/20 | 0.38 |
| ▸ | CDYL | Q9Y232 | 3/20 | 0.38 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 3/20 | 0.38 |
| ▸ | CBX7 | O95931 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621007 | 0.83 | POLB (0.51) | LMNACYP1A2CYP2C19POLBCYP3A4 | |
| Trifluoroacetic Acid SCHEMBL4618886 | 0.80 | POLB (0.38) | LMNACYP1A2CYP2C19POLBCYP3A4 | |
| SCHEMBL4158065 | 0.80 | CES1 (0.45) | KMT2AALDH1A1 | |
| SCHEMBL4161122 | 0.78 | NPC1 (0.46) | KMT2ASMN1; SMN2MEN1 | |
| Trifluoroacetic Acid SCHEMBL4622701 | 0.78 | CHRM1 (0.46) | — | |
| Trifluoroacetic Acid SCHEMBL4158022 | 0.77 | HDAC1 (0.38) | SMN1; SMN2 | |
| SCHEMBL4171678 | 0.76 | HPGD (0.40) | CYP1A2CYP2C19CYP3A4KMT2AIDO1 | |
| SCHEMBL4151885 | 0.73 | KMT2A (0.43) | LMNACYP1A2CYP2C19POLBCYP3A4 | |
| SCHEMBL4159834 | 0.73 | EPHX2 (0.43) | LMNACYP1A2CYP2C19CYP3A4CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL4171443 | 0.72 | CHRM1 (0.38) | LMNACYP1A2CYP2C19POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |