Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 7/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158065 | 0.86 | CES1 (0.45) | HDAC1HDAC2CES1KMT2A | |
| SCHEMBL4159834 | 0.83 | EPHX2 (0.43) | NPC1RAB9ASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL4163977 | 0.83 | MLYCD (0.46) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL4158022 | 0.83 | HDAC1 (0.38) | NPC1RAB9ASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL3507605 | 0.81 | GPR139 (0.42) | GPR139SLC6A9SLC6A5HDAC1HDAC2 | |
| SCHEMBL4160412 | 0.81 | HTT (0.46) | NPC1RAB9AGPR139HDAC1HDAC2 | |
| SCHEMBL4166649 | 0.79 | HDAC1 (0.38) | NPC1RAB9ASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL4149913 | 0.79 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4620748 | 0.78 | LMNA (0.40) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4161127 | 0.74 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2GPR139SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | NPC1 1625/4885RAB9A 1138/4885SMN1; SMN2 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.