Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | ILK | Q13418 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 5/20 | 0.46 |
| ▸ | ATP4A | P20648 | 4/20 | 0.45 |
| ▸ | ATP4B | P51164 | 4/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PI4KA | P42356 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386262 | 0.79 | FYN (0.60) | FYNCHEK2ATRATM | |
| SCHEMBL4621168 | 0.76 | CHEK2 (0.77) | FYNCHEK2ATRATMTGFBR1 | |
| SCHEMBL2748397 | 0.76 | PRKD3 (0.53) | FYNCHEK2ILKRAB9AKMT2A | |
| SCHEMBL18613239 | 0.75 | FYN (1.00) | FYNCHEK2ATRATMACVR1B | |
| SCHEMBL30521926 | 0.75 | FYN (1.00) | FYNCHEK2ATRATMACVR1B | |
| SCHEMBL2749468 | 0.74 | TP53 (0.47) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2750376 | 0.74 | ATR (0.54) | FYNATRILK | |
| SCHEMBL2750714 | 0.74 | CHEK2 (0.55) | CHEK2ATRATMPIK3CDPIK3CA | |
| SCHEMBL2750324 | 0.74 | ILK (0.65) | ATRILKATMMEN1NPC1 | |
| SCHEMBL1982607 | 0.73 | KDM4E (0.51) | ILKMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178668-B2 | 2-aminopyridine kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197862-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | ERBB2, ABL2, TIE1 | FYN 75/4885CHEK2 121/4885ATR 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.