Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621627 | 0.88 | MAP3K5 (0.40) | MAP3K5GRM4ADORA3GNRHRKDM4E | |
| SCHEMBL9014099 | 0.73 | ALOX15 (0.47) | MAP3K5KDM4EMEN1KMT2A | |
| SCHEMBL4233423 | 0.71 | RAD52 (0.44) | RAD52GNRHRLCK | |
| SCHEMBL4241622 | 0.71 | RAD52 (0.36) | RAD52KCNQ3KCNQ2ADORA3GNRHR | |
| SCHEMBL4621316 | 0.68 | ACHE (0.39) | RAD52CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4228231 | 0.68 | RAD52 (0.41) | RAD52ADORA3GNRHRLCK | |
| SCHEMBL29050260 | 0.67 | KDM4E (0.46) | MAP3K5GRM4KDM4EPIM1 | |
| SCHEMBL4233328 | 0.67 | ABCB1 (0.34) | KCNQ3KCNQ2GNRHR | |
| Maleic Acid SCHEMBL27389854 | 0.67 | KDM4E (0.46) | MAP3K5KDM4EMEN1KMT2A | |
| SCHEMBL4231696 | 0.66 | HRH3 (0.41) | RAD52CSNK2A2CSNK2BCSNK2A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896465-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | Takeda Cambridge Limited (GB) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007000582-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | TAKEDA CAMBRIDGE LIMITED (GB) | 2007-01-04 | — | — | WO | disclosed |