SCHEMBL462151

SCHEMBL462151

O=C(O)C(CC=CF)=C(CC=CF)C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
CYP2D6 P10635 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9576323 0.89
SCHEMBL2100821 0.77
SCHEMBL15546576 0.77
SCHEMBL10887729 0.75 FNTA (0.31) ALDH1A1CYP2D6ALOX15
Ammonia Solution, Strong SCHEMBL5138978 0.74
SCHEMBL27467254 0.74
Potassium SCHEMBL4960943 0.74
SCHEMBL9799550 0.74 ALDH1A1 (0.38) ALDH1A1CYP2D6ALOX15
SCHEMBL28322476 0.73 ALDH1A1 (0.35) ALDH1A1CYP2D6ALOX15
SCHEMBL8943586 0.72 ALDH1A1 (0.36) ALDH1A1CYP2D6ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0219884-B1 HARD CONTACT LENS MATERIAL Tomei Sangyo Kabushiki Kaisha (JP) 1993-09-29 EP claimed
JP-4168415-A None JP disclosed
US-8101701-B2 having a hydrophilic group and a silicon-containing alkyl group within molecule; lenses with high oxygen permeability independent from the water content may be obtained, wherein the fumaric acid derivatives is superior in compatibility with the hydrophilic monomer used in combination MENICON NECT CO., LTD. (JP) 2012-01-24 US disclosed
EP-1930338-A1 Fumaric acid derivates and ophtalmic lenses using the same E-brain Corporation Ltd. (JP) 2008-06-11 EP disclosed
US-20080132666-A1 Fumaric Acid Derivatives and Ophthalmic Lenses Using the Same MENICON NECT CO., LTD. (JP) 2008-06-05 US disclosed
EP-0219884-B1 HARD CONTACT LENS MATERIAL Tomei Sangyo Kabushiki Kaisha (JP) 1993-09-29 EP disclosed
JP-H04168415-A CONTACT LENS MENICON CO LTD 1992-06-16 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080132666-A1 Fumaric Acid Derivatives and Ophthalmic Lenses Using the Same FAH, FH, AQP4 ALDH1A1 741/4885CYP2D6 3099/4885ALOX15 290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.