Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 9/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.59 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.57 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | USP7 | Q93009 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17027779 | 0.76 | PDGFRB (0.58) | CHEK2CHEK1CYP2A6IKBKETBK1 | |
| SCHEMBL17067720 | 0.76 | PDGFRB (0.58) | CHEK2CHEK1CYP2A6IKBKETBK1 | |
| SCHEMBL13035228 | 0.74 | CYP2A6 (1.00) | CHEK2CHEK1CYP2A6EPHX2KDR | |
| SCHEMBL14059984 | 0.74 | TBK1 (1.00) | CHEK2CHEK1IKBKETBK1 | |
| SCHEMBL1356085 | 0.73 | CYP17A1 (0.70) | CHEK2CYP2A6IKBKETBK1KDR | |
| SCHEMBL18613577 | 0.73 | FYN (1.00) | CHEK2FYNUSP7MAP4K4 | |
| SCHEMBL992459 | 0.72 | ERN1 (0.53) | CHEK2CHEK1CYP2A6IKBKETBK1 | |
| SCHEMBL29582823 | 0.71 | FYN (0.53) | CHEK2CYP2A6FYNUSP7MAP4K4 | |
| SCHEMBL26916746 | 0.71 | FYN (0.53) | CHEK2CYP2A6FYNUSP7MAP4K4 | |
| SCHEMBL5322817 | 0.70 | CYP2A6 (0.55) | CHEK2CHEK1CYP2A6MAP4K4PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |