Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245867 | 0.90 | MMP2 (0.40) | SMN1; SMN2L3MBTL1ITKALDH1A1 | |
| SCHEMBL2245162 | 0.87 | ERN1 (0.36) | KMT2AMEN1ALDH1A1LMNAKIF11 | |
| SCHEMBL2244927 | 0.87 | PPARG (0.37) | L3MBTL1TDP1ALDH1A1LMNATSHR | |
| SCHEMBL2245097 | 0.87 | KMT2A (0.37) | KMT2AHSP90AA1MEN1MAPK1SMN1; SMN2 | |
| SCHEMBL2247320 | 0.86 | MMP2 (0.35) | KMT2AMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL2245193 | 0.86 | MMP2 (0.43) | KMT2AMEN1MAPK1TDP1ALDH1A1 | |
| SCHEMBL2245812 | 0.85 | HDAC1 (0.37) | SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL27708299 | 0.85 | RORC (0.35) | ITKCYP3A4 | |
| SCHEMBL2247635 | 0.84 | MCHR1 (0.36) | ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2252602 | 0.83 | TP53 (0.35) | L3MBTL1ALDH1A1LMNAKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | claimed |
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |