Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL4937450 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TSHRLMNACYP3A4GABRA1 | |
| Lindane SCHEMBL842762 | 0.79 | LMNA (0.50) | TSHRLMNACYP3A4GABRA1GABRB1 | |
| Monoethanolamine SCHEMBL5985807 | 0.79 | — | — | |
| Lindane SCHEMBL5889386 | 0.79 | LMNA (0.50) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Monoethanolamine SCHEMBL1331364 | 0.78 | — | — | |
| Monoethanolamine SCHEMBL1332111 | 0.78 | — | — | |
| Monoethanolamine SCHEMBL1644 | 0.78 | — | — | |
| Monoethanolamine SCHEMBL14675689 | 0.78 | TSHR (1.00) | ALDH1A1TSHRLMNACYP3A4 | |
| Monoethanolamine SCHEMBL29663853 | 0.78 | — | — | |
| Monoethanolamine SCHEMBL10941117 | 0.78 | TSHR (1.00) | ALDH1A1TSHRLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898922-A2 | IMPROVED DRUG OR PHARMACEUTICAL COMPOUNDS AND A PREPARATION THEREOF | Krishnan, Ramu (IN) | 2008-03-19 | — | — | EP | claimed |
| WO-2007004236-A2 | IMPROVED DRUG OR PHARMACEUTICAL COMPOUNDS AND A PREPARATION THEREOF | KRISHNAN RAMU (IN) | 2007-01-11 | — | — | WO | claimed |