Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.42 |
| ▸ | PDIA4 | P13667 | 2/20 | 0.42 |
| ▸ | PDIA3 | P30101 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA6 | P23280 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622327 | 1.00 | POLB (0.50) | POLBTSHRCA12CA1CA9 | |
| SCHEMBL4959831 | 1.00 | POLB (0.50) | POLBTSHRCA12CA1CA9 | |
| SCHEMBL4959838 | 1.00 | POLB (0.50) | POLBTSHRCA12CA1CA9 | |
| SCHEMBL2037083 | 0.84 | POLB (0.58) | POLBTSHRCA12CA1CA9 | |
| SCHEMBL28330817 | 0.78 | TSHR (0.47) | POLBTSHRCYP2D6P4HBPDIA4 | |
| SCHEMBL18343933 | 0.76 | CYP2D6 (0.40) | POLBTSHRCA12CA1CA9 | |
| SCHEMBL7155618 | 0.73 | CYP2D6 (0.51) | TSHRCA12CA1CA9CA2 | |
| SCHEMBL8744183 | 0.73 | CYP2D6 (0.51) | TSHRCA12CA1CA9CA2 | |
| SCHEMBL7045459 | 0.73 | CYP2D6 (0.51) | TSHRCA12CA1CA9CA2 | |
| SCHEMBL7155622 | 0.73 | CYP2D6 (0.51) | TSHRCA12CA1CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |