Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CPA3 | P15088 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | EPOR | P19235 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27826145 | 0.77 | TRPM8 (0.46) | KDM4ECPA3MEN1KMT2AEPOR | |
| SCHEMBL27516787 | 0.75 | NPY4R (0.37) | — | |
| SCHEMBL7751685 | 0.75 | NPY4R (0.37) | — | |
| Hydrochloric Acid SCHEMBL8630191 | 0.74 | MEN1 (0.44) | ALDH1A1LMNACPA3MEN1KMT2A | |
| SCHEMBL2245317 | 0.73 | PTPN1 (0.40) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL2246888 | 0.73 | PTPN1 (0.40) | ALDH1A1LMNAKMT2APOLBHSD17B10 | |
| SCHEMBL4623203 | 0.73 | NPC1 (0.43) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL5652505 | 0.72 | KMT2A (0.40) | ALDH1A1LMNACPA3MEN1KMT2A | |
| SCHEMBL11599332 | 0.72 | L3MBTL1 (0.40) | ALDH1A1LMNACPA3MEN1KMT2A | |
| SCHEMBL9200349 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |