SCHEMBL4622607

SCHEMBL4622607

O=C(O)CCCCC(=O)c1ccc(Cl)cc1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.51
ALDH1A1 P00352 2/20 0.45
POLB P06746 2/20 0.45
OXER1 Q8TDS5 3/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
KMO O15229 1/20 0.43
MAPT P10636 2/20 0.43
RAB9A P51151 2/20 0.43
NPSR1 Q6W5P4 2/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11582407 0.90 CA1 (0.47) HTTALDH1A1POLBCA1CA2
SCHEMBL6076034 0.85 CA1 (0.59) HTTALDH1A1POLBOXER1CA1
SCHEMBL13346899 0.83 ALDH1A1 (0.62) ALDH1A1POLBOXER1SMN1; SMN2MAPT
SCHEMBL31661827 0.81 ERCC5 (0.58) ALDH1A1POLBOXER1SMN1; SMN2MAPT
SCHEMBL5081080 0.81 ERCC5 (0.58) ALDH1A1POLBOXER1SMN1; SMN2MAPT
SCHEMBL4624101 0.81 HTT (0.43) HTTALDH1A1POLBCA1CA2
SCHEMBL4390458 0.80 CDK1 (0.56) ALDH1A1POLBCA1CA2HDAC3
SCHEMBL4624098 0.80 HTT (0.46) HTTALDH1A1CA1CA2SMN1; SMN2
SCHEMBL15619155 0.80 ERCC5 (0.57) ALDH1A1POLBOXER1SMN1; SMN2MAPT
SCHEMBL30808872 0.80 ERCC5 (0.57) ALDH1A1POLBOXER1SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1322595-B1 (5-(2-HYDROXY-4-CHLOROBENZOYL) AMINOVALERIC ACID AND SALTS THEREOF AND COMPOSITIONS CONTAINING THE SAME FOR DELIVERING ACTIVE AGENTS EMISPHERE TECH INC (US) 2008-05-28 EP disclosed
EP-1322595-A4 (5-(2-HYDROXY-4-CHLOROBENZOYL) AMINOVALERIC ACID AND SALTS THEREOF AND COMPOSITIONS CONTAINING THE SAME FOR DELIVERING ACTIVE AGENTS EMISPHERE TECH INC (US) 2005-03-23 EP disclosed
EP-1322595-A2 (5-(2-HYDROXY-4-CHLOROBENZOYL) AMINOVALERIC ACID AND SALTS THEREOF AND COMPOSITIONS CONTAINING THE SAME FOR DELIVERING ACTIVE AGENTS Emisphere Technologies, Inc. (US) 2003-07-02 EP disclosed