SCHEMBL4622980

SCHEMBL4622980

Nc1c(O)c(F)c(Oc2c(F)c(F)c(-c3c(F)c(F)c(Oc4c(F)c(O)c(N)c(F)c4F)c(F)c3F)c(F)c2F)c(F)c1F

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
CRHBP P24387 1/20 0.32
CRHR2 Q13324 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7552402 0.93 MAPT (0.35) KDM4EMAPTCRHBPCRHR2
SCHEMBL4750265 0.93 MAPT (0.35) KDM4EMAPTCRHBPCRHR2
SCHEMBL1334193 0.84 MAPT (0.38) KDM4EMAPTCRHBPCRHR2
SCHEMBL3623855 0.79 MAPT (0.35) KDM4EMAPTCRHBPCRHR2
SCHEMBL7800107 0.79 HPGD (0.51)
SCHEMBL31465318 0.77 KDM4E (0.32) KDM4EMAPTCRHBPCRHR2
SCHEMBL6757630 0.76 HSD17B10 (0.38)
SCHEMBL722867 0.75 MAPT (0.42) KDM4EMAPTCRHBPCRHR2
Hydrochloric Acid SCHEMBL6756049 0.74 HSD17B10 (0.37)
SCHEMBL29962494 0.72 MAPT (0.33) KDM4EMAPTCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0905169-B1 Precursors of polybenzoxazoles and polybenzothiazoles INFINEON TECHNOLOGIES AG (DE) 2008-04-02 EP disclosed
EP-0906903-B1 Bis-o-amino(thio)phenols and their preparartion INFINEON TECHNOLOGIES AG (DE) 2001-12-12 EP disclosed
US-6150558-A Bis-o-amino(thio)phenols, and their preparation SIEMENS AKTIENGESELLSCHAFT (DE) 2000-11-21 US disclosed
EP-0906903-A2 Bis-o-amino(thio)phenols and their preparartion SIEMENS AKTIENGESELLSCHAFT (DE) 1999-04-07 EP disclosed
EP-0905169-A2 Precursors of polybenzoxazoles and polybenzothiazoles SIEMENS AKTIENGESELLSCHAFT (DE) 1999-03-31 EP disclosed