Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623217 | 0.81 | HCAR2 (0.58) | KDM4CHCAR2DAO | |
| SCHEMBL4620729 | 0.75 | HCAR2 (0.68) | KDM4CHCAR2HCAR3NPC1HDAC8 | |
| SCHEMBL4648485 | 0.74 | HCAR2 (0.61) | KDM4CHCAR2HCAR3MEN1KMT2A | |
| SCHEMBL4648477 | 0.74 | MEN1 (0.39) | HCAR2HCAR3MEN1KMT2ADAO | |
| SCHEMBL4646434 | 0.73 | HCAR2 (0.38) | KDM4CHCAR2MEN1KMT2ADAO | |
| SCHEMBL4648872 | 0.70 | HCAR3 (0.64) | KDM4CHCAR2HCAR3MEN1KMT2A | |
| SCHEMBL3516314 | 0.69 | MEN1 (0.55) | HCAR2HCAR3MEN1KMT2ADAO | |
| SCHEMBL15286846 | 0.69 | KDM4C (1.00) | KDM4C | |
| SCHEMBL4649196 | 0.68 | HCAR3 (0.53) | KDM4CHCAR2HCAR3 | |
| Hydrochloric Acid SCHEMBL15286204 | 0.68 | KDM4C (0.97) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | claimed |
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |